The murine goblet cell protein mCLCA3 is a zinc-dependent metalloprotease with autoproteolytic activity
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چکیده
منابع مشابه
An archaeal protein evolutionarily conserved in prokaryotes is a zinc-dependent metalloprotease
A putative protease gene (tldD) was previously identified from studying tolerance of letD encoding the CcdB toxin of a toxin-antidote system of the F plasmid in Escherichia coli. While this gene is evolutionarily conserved in archaea and bacteria, the proteolytic activity of encoded proteins remained to be demonstrated experimentally. Here we studied Sso0660, an archaeal TldD homologue encoded ...
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متن کاملThe Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice
The secreted, goblet cell-derived protein Clca1 (chloride channel regulator, calcium-activated-1) has been linked to diseases with mucus overproduction, including asthma and cystic fibrosis. In the intestine Clca1 is found in the mucus with an abundance and expression pattern similar to Muc2, the major structural mucus component. We hypothesized that Clca1 is required for the synthesis, structu...
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ژورنال
عنوان ژورنال: Molecules and Cells
سال: 2011
ISSN: 1016-8478,0219-1032
DOI: 10.1007/s10059-011-0158-8